The topic of this paper is social work and families of children with developmental disabilities. The paper explains who are children with developmental disabilities, the process of adaptation of family members of children with developmental disabilities and the assistance that social work can provide to families of children with developmental disabilities. Children with developmental disabilities are children with disabilities that occur in childhood. This may be: visual impairment, intellectual disability, behavioral disorders and mental health impairment, hearing impairment, language-voice-speech communication, learning difficulties and other organ damage. Family is a natural and basic unit in society and is entitled to the protection. Family is very important to every individual, and if the child has developmental disabilities, all family members are affected to a certain point. Each family is different, but every family needs time to accept developmental difficulties of child. Social work with families of children work on empowering families, providing family support, bringing family members together and informing families about their rights, and working to reduce the stigma that is attached to developmental disabilities. Social work in the Republic of Croatia with families of children with developmental disabilities is taking place through the government's social welfare system and not-for-profit organizations.