This paper presents the problem of social exclusion of homeless people in Republic of Croatia. First chapter defines the term homelessness, as well as individual and structural causes of homelessness. Homelessness represents extreme form od poverty and social work is one of the professions that is best acquainted with the topic of povery. Therefore, the role of social work in the fight against poverty is emphasized, as well as the methods and means that social workers should be using in the fight against this social problem. The third chapter handles the topic of social exclusion, which refers to multiple deprivation of an individual and his non-participation and secession from society. Homeless people are excluded from all social systems. Stigma refers to attribution of negative traits to homeless people and it hinders their progress. Concise review of legislation related to homeless people which are recognised as beneficiaries in the social welfare system. The role of social work, as a helping profesion, is shown, as well as listed present social services in the public and private sector that are intended for the homeless people. Finally, it can be assumed that homelessness is a serious and neglected social problem which presents a challenge for numerous professions and in whose resolving there are significant omissions exist.