In the process of harmonisation its national legislation with the legislation of the European union, and as party of entire key international treaties in the field of social and economy security of the citizens, the Republic of Croatia has adopted legal frame aimed to eliminate discrimination of persons with disabilities and enable them to enjoy and to fulfil their fundamental economic right – the right to work. Thus, the aim of this paper is to research within the context of the obligations which The Republic of Croatia had adopted primarily by ratification of the Convention on the Rights of Persons with Disabilities as well as in the context of Directive 2000/78/EC and Law on professional rehabilitation and employment of persons with disabilities, whether the terms related to their employment and work i.e. whether the persons with disabilities in Croatia achieve the right to work and at which level with special attention to positive measures aimed at their employment i.e. reasonable adjustment and quota system. The role of ombudsman for persons with disabilities on protection and work has been analysed in the paper and especially in the segment of protection from discrimination and unequal treatment at the processes of employment and work. Legislation of the Federal Republic of Germany has been analysed in the field of employment of persons with disabilities as well as legal sources of the European union judicial decision of Court of Justice of the European union. In the paper special attention has also been given to the research of whether and at which level educational institutions, health institutions and the social welfare institutions in Pozega-slavonia county respect legal provisions related to employment quota and obligation of reasonable adjustment of work places, conditions and organisation of work for people with disabilities.