People with disabilities belong to one of the most vulnerable groups that need special protection from the state and society. Business ability allows us to create legal effects and make decisions related to our life, and for a person with a disability, this property is usually limited. The work is focused on the problems faced by persons with disabilities when it comes to the institution of guardianship and on certain provisions contained in the Convention on the Rights of Persons with Disabilities in the Family Law of the Republic of Croatia. The Convention on the Rights of Persons with Disabilities is a fundamental document that contains provisions aimed at protecting the fundamental rights of persons with disabilities, but the application of these provisions is often not so easily implemented in practice. This paper also shows the gap between the provisions of the Family Law and what is required by the Convention on the Rights of Persons with Disabilities, and it is also focused on the issue of abolishing the complete deprivation of business capacity. When it comes to the autonomy of people with disabilities in making life-important decisions, the substitute decision-making regime needs to be replaced by supported decision-making in order to enable a person with a disability to enjoy human rights on an equal basis with others. Social services play a major role in the institution of guardianship in work with residents and their families, and the empowerment of people with disabilities in the form of strengthening their capacities and the creation of autonomy and independence.